3DChem.com - Chemistry, Structures & 3D Molecules a visual and interactive website showcasing the beautiful world of chemistry

Temocillin (Molecule of the Month for March 2011)


Temocillin is a β-lactamase resistant carboxypenicillin. introduced by Beecham, marketed by Eumedica Pharmaceuticals as primarily for the treatment of multiresistant Gram negative bacteria, such as Salmonella and Escherichia coli. It is not active against Gram positive bacteria or bacteria with altered penicillin-binding proteins. The common dosage is 2g intravenously every 12 hours.

The term "antibiotic" was coined by Selman Waksman in 1942 to describe any substance produced by a microorganism that is antagonistic to the growth of other microorganisms in high dilution. This definition excluded substances that kill bacteria but are not produced by microorganisms (such as gastric juices and hydrogen peroxide). It also excluded synthetic antibacterial compounds such as the sulfonamides. Many antibacterial compounds are relatively small molecules with a molecular weight of less than 2000 atomic mass units.

With advances in medicinal chemistry, most of today's antibacterials chemically are semisynthetic modifications of various natural compounds. These include, for example, the beta-lactam antibacterials, which include the penicillins (produced by fungi in the genus 'Penicillium'), the cephalosporins, and the carbapenems. Compounds that are still isolated from living organisms are the aminoglycosides, whereas other antibacterials—for example, the sulfonamides, the quinolones, and the oxazolidinones—are produced solely by chemical synthesis.

Formal Chemical Name (IUPAC)

Picture of Temocillin 3D model

click on the picture of  Temocillin above to interact
with the 3D model of the
Temocillin structure
(this will open a new browser window)

Picture of Temocillin

Update by Karl Harrison
(Molecule of the Month for March 2011 )

Stacks Image 34 All the images on this web site are are made available with a Creative Commons Attribution license and so can be used as long as the attribution © Karl Harrison 3DChem.com is written with the image. High resolution images and illustrations are available on request.