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Rivastigmine (Molecule of the Month for October 2006)

Exelon, Prometax

Rivastigmine is an acetyl cholinesterase inhibitor that was developed by Novartis for the treatment of mild to moderate Alzheimer’s dementia.

In 2001, National Institute for Health and Clinical Excellence (NICE) has recommended that the three drugs donepezil, rivastigmine and galantamine should be made available in the NHS as one part of the management of some people with mild and moderate Alzheimer's disease.

However in 2006, NICE reversed its recommendation after appeal by the manufactures and said donepezil, rivastigmine and galantamine could be used to treat moderate stage disease, also NICE ruled another drug, memantine, should be used only in clinical studies for people with moderately severe to severe Alzheimer's disease. This means the early onset on Alzheimer's disease in its mild form cannot be treated by these drugs here in the UK.

Formal Chemical Name (IUPAC)
3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)carbamate




Picture of Rivastigmine 3D model

click on the picture of  Rivastigmine above to interact
with the 3D model of the
Rivastigmine structure
(this will open a new browser window)

Picture of Rivastigmine

C14 H22 N2 O2

Update by Karl Harrison
(Molecule of the Month for October 2006 )

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