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Naproxen (Molecule of the Month for May 2004)

Aleve, Anaprox, Naprosyn, Naprelan

Naproxen is a non-steroidal anti-inflammatory drug (NSAID) commonly used for the reduction of mild to moderate pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, injury, menstrual cramps, tendinitis, bursitis, and the treatment of primary dysmenorrhea. It works by reducing hormones that cause inflammation and pain in the body

Naproxen was first sold as the prescription drug Naprosyn in 1976; naproxen sodium was first sold under the trade name Anaprox in 1980. The Food and Drug Administration (FDA) approved naproxen sodium's use as an over-the-counter drug in 1994. Naproxen is still a prescription drug in much of the world, including Canada.

Although naproxen typically requires a higher dosage than other NSAIDs a minimal dose is about 200 mg it binds very well to albumin and thus achieves a longer half-life in the blood than other drugs, lasting up to 12 hours per dose. Naproxen is also available as a sodium salt, naproxen sodium, which is more rapidly absorbed from the gastrointestinal tract.

Formal Chemical Name (IUPAC)
(S)-6-methoxy-?-methyl-2-naphthaleneacetic acid



Picture of Naproxen 3D model

click on the picture of  Naproxen above to interact
with the 3D model of the
Naproxen structure
(this will open a new browser window)

Picture of Naproxen


Update by Karl Harrison
(Molecule of the Month for May 2004 )

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