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Febrifugine (Molecule of the Month for July 2012)

Febrifugine is a quinazolinone alkaloid first isolated from Chinese herb Dichroa febrifuga, but also found in the garden plant Hydrangea. Febrifugine has antimalarial properties and the halogenated derivative halofuginone is used in veterinary medicine as a coccidiostat.

Febrifugine is the active principal isolated 50 years ago from the Chinese herb chang shan (Dichroa febrifuga Lour), which has been used as an antimalarial in Chinese traditional medicine for more than 2,000 years. However, intensive study of the properties of febrifugine has been hindered for decades due to its side effects.

The side effects of febrifugine and its analogs mainly include diarrhea and gastrointestinal hemorrhage.

Formal Chemical Name (IUPAC)




Picture of Febrifugine 3D model

click on the picture of  Febrifugine above to interact
with the 3D model of the
Febrifugine structure
(this will open a new browser window)

Picture of Febrifugine


Update by Karl Harrison
(Molecule of the Month for July 2012 )

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