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Cyclosporin A (Molecule of the Month for March 1996)


Immunosuppressive medications play a large part of the management of many pediatric illnesses.

Cyclosporine is the primary tool used to prevent rejection following solid organ and bone marrow transplantation . It has been estimated that cyclosporine is given to more than 90% of children who have received a kidney transplant in the United States.

In addition, the ability of cyclosporine to inhibit T-cell activation has been shown to have a role in the treatment of diseases such as nephrotic syndrome, refractory Crohn's disease and ulcerative colitis, biliary cirrhosis, aplastic anemia, rheumatoid arthritis, myasthenia gravis, and dermatomyositis.

Cyclosporin A is the active ingredient in the Sandoz medication Sandimmun. The Pharmaceuticals company Sandoz is now owned by Novartis http://www.pharma.novartis.com/ and they now market the product Sandimmum.

Sandimmun acts in a very specific way to suppress rejection of transplanted organs by the body's immune system.

Formal Chemical Name (IUPAC)

Picture of Cyclosporin A 3D model

click on the picture of  Cyclosporin A above to interact
with the 3D model of the
Cyclosporin A structure
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Picture of Cyclosporin A

Update by Karl Harrison
(Molecule of the Month for March 1996 )

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