Chrysophanol (Molecule of the Month for December 2018)
Chrysophanol a natural anthraquinone. It has been isolated from Aloe vera and exhibits antiviral and anti-inflammatory activity. It has a role as an antiviral agent, an anti-inflammatory agent and a plant metabolite. Chrysophanol is also found in the Chinese herb R. palmatum and also as a marine fungal isolate.
Chrysophanol blocks the proliferation of colon cancer cells in vitro. It induces the necrosis of cells via a reduction in ATP levels.
Chrysophanol attenuates the effects of lead exposure in mice by reducing hippocampal neuronal cytoplasmic edema, enhancing mitochondrial crista fusion, significantly increasing memory and learning abilities, reducing lead content in blood, heart, brain, spleen, kidney and liver, promoting superoxide dismutase and glutathione peroxidase activities and reducing malondialdehyde level in the brain, kidney and liver
Update by Karl Harrison
(Molecule of the Month for December 2018 )
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