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Amoxicillin and clavulanate potassium are are penicillin antibiotics. Amoxicillin and clavulanate potassium fights bacteria in the body. Amoxicillin and clavulanate potassium is used to treat many different types of bacterial infections, such as sinusitis, pneumonia, ear infections, bronchitis, urinary tract infections, and infections of the skin.