http://www.3dchem.com Molecule of the Month Updates en-gb Wed, 22 May 2013 00:00:00 GMT Copyright: (C) Karl Harrison http://www.3dchem.com 12 http://www.3dchem.com/molecules.asp?id=506http://www.3dchem.com/molecules.asp?id=506Omacetaxine mepesuccinate is an alkaloid from Cephalotaxus harringtonia that is indicated for treatment of Chronic Myelogenous Leukemia. Cephalotaxus harringtonia, commonly known as Cowtail Pine or Japanese Plum Yew, is a coniferous bush or small tree in the plum yew family. It is native to Japan, but is occasionally utilised in western gardens and several cultivars exist for these purposes. Japanese plum yew has been in cultivation in Europe since 1829, many modern horticulturists are familiar with the Japanese species Cephalotaxus harringtonia, named in honor of the Earl of Harrington, one of the first to grow the plant in a European garden. An Australian company, ChemGenex Pharmaceuticals Ltd., is developing a leukemia therapy called Omacetaxine derived from the leaves of this yew species.Tue, 2 Apr 2013 00:00:00 GMT http://www.3dchem.com/molecules.asp?id=507http://www.3dchem.com/molecules.asp?id=507Omacetaxine mepesuccinate is an alkaloid from Cephalotaxus harringtonia that is indicated for treatment of Chronic Myelogenous Leukemia. Cephalotaxus harringtonia, commonly known as Cowtail Pine or Japanese Plum Yew, is a coniferous bush or small tree in the plum yew family. It is native to Japan, but is occasionally utilised in western gardens and several cultivars exist for these purposes. Japanese plum yew has been in cultivation in Europe since 1829, many modern horticulturists are familiar with the Japanese species Cephalotaxus harringtonia, named in honor of the Earl of Harrington, one of the first to grow the plant in a European garden. An Australian company, ChemGenex Pharmaceuticals Ltd., is developing a leukemia therapy called Omacetaxine derived from the leaves of this yew species.Tue, 2 Apr 2013 00:00:00 GMT http://www.3dchem.com/molecules.asp?id=505http://www.3dchem.com/molecules.asp?id=505Khellin is a furanochromone, an organic compound which is derivative of chromone (1,4-benzopyrone) and furan. It has lipophilic properties and causes vasodilation (widening of blood vessels). Sat, 2 Mar 2013 00:00:00 GMT http://www.3dchem.com/molecules.asp?id=504http://www.3dchem.com/molecules.asp?id=504Papaverine (lat. papaver, "poppy") is an opium alkaloid antispasmodic drug, used primarily in the treatment of visceral spasm, vasospasm (especially those involving the heart and the brain), and occasionally in the treatment of erectile dysfunction. While it is found in the opium poppy, papaverine differs in both structure and pharmacological action from the analgesic (morphine-related) opium alkaloids (opioids).Sat, 2 Feb 2013 00:00:00 GMT http://www.3dchem.com/molecules.asp?id=503http://www.3dchem.com/molecules.asp?id=503Ricinoleic acid is an unsaturated omega-9 fatty acid that naturally occurs in mature Castor plant (Ricinus communis L., Euphorbiaceae) seeds or in sclerotium of ergot (Claviceps purpurea Tul., Clavicipitaceae). About 90% of the fatty acid content in castor oil is the triglyceride formed from ricinoleic acid.Wed, 2 Jan 2013 00:00:00 GMT http://www.3dchem.com/molecules.asp?id=502http://www.3dchem.com/molecules.asp?id=502Methoxsalen is a drug used to treat psoriasis, eczema, vitiligo, and some cutaneous lymphomas in conjunction with exposing the skin to sunlight. Methoxsalen modifies the way skin cells receive the UVA radiation, allegedly clearing up the disease. The dosage comes in 10 mg tablets, which are taken in the amount of 30 mg 75 minutes before a PUVA (psoralen + UVA) light treatment. Sun, 2 Dec 2012 00:00:00 GMT http://www.3dchem.com/molecules.asp?id=493http://www.3dchem.com/molecules.asp?id=493Senna (from Arabic sanā), the sennas, is a large genus of flowering plants in the family Fabaceae, subfamily Caesalpinioideae. This diverse genus is native throughout the tropics, with a small number of species reaching into temperate regions. The number of species is usually estimated to be about 300.Fri, 2 Nov 2012 00:00:00 GMT http://www.3dchem.com/molecules.asp?id=494http://www.3dchem.com/molecules.asp?id=494Senna (from Arabic sanā), the sennas, is a large genus of flowering plants in the family Fabaceae, subfamily Caesalpinioideae. This diverse genus is native throughout the tropics, with a small number of species reaching into temperate regions. The number of species is usually estimated to be about 300.Fri, 2 Nov 2012 00:00:00 GMT http://www.3dchem.com/molecules.asp?id=495http://www.3dchem.com/molecules.asp?id=495Senna (from Arabic sanā), the sennas, is a large genus of flowering plants in the family Fabaceae, subfamily Caesalpinioideae. This diverse genus is native throughout the tropics, with a small number of species reaching into temperate regions. The number of species is usually estimated to be about 300.Fri, 2 Nov 2012 00:00:00 GMT http://www.3dchem.com/molecules.asp?id=496http://www.3dchem.com/molecules.asp?id=496Senna (from Arabic sanā), the sennas, is a large genus of flowering plants in the family Fabaceae, subfamily Caesalpinioideae. This diverse genus is native throughout the tropics, with a small number of species reaching into temperate regions. The number of species is usually estimated to be about 300.Fri, 2 Nov 2012 00:00:00 GMT http://www.3dchem.com/molecules.asp?id=499http://www.3dchem.com/molecules.asp?id=499Senna (from Arabic sanā), the sennas, is a large genus of flowering plants in the family Fabaceae, subfamily Caesalpinioideae. This diverse genus is native throughout the tropics, with a small number of species reaching into temperate regions. The number of species is usually estimated to be about 300.Tue, 2 Oct 2012 00:00:00 GMT http://www.3dchem.com/molecules.asp?id=498http://www.3dchem.com/molecules.asp?id=498Senna (from Arabic sanā), the sennas, is a large genus of flowering plants in the family Fabaceae, subfamily Caesalpinioideae. This diverse genus is native throughout the tropics, with a small number of species reaching into temperate regions. The number of species is usually estimated to be about 300.Tue, 2 Oct 2012 00:00:00 GMT http://www.3dchem.com/molecules.asp?id=500http://www.3dchem.com/molecules.asp?id=500Senna (from Arabic sanā), the sennas, is a large genus of flowering plants in the family Fabaceae, subfamily Caesalpinioideae. This diverse genus is native throughout the tropics, with a small number of species reaching into temperate regions. The number of species is usually estimated to be about 300.Tue, 2 Oct 2012 00:00:00 GMT http://www.3dchem.com/molecules.asp?id=497http://www.3dchem.com/molecules.asp?id=497Senna (from Arabic sanā), the sennas, is a large genus of flowering plants in the family Fabaceae, subfamily Caesalpinioideae. This diverse genus is native throughout the tropics, with a small number of species reaching into temperate regions. The number of species is usually estimated to be about 300.Tue, 2 Oct 2012 00:00:00 GMT http://www.3dchem.com/molecules.asp?id=501http://www.3dchem.com/molecules.asp?id=501Miglitol is an oral anti-diabetic drug that acts by inhibiting the ability of the patient to break down complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the body.Sun, 2 Sep 2012 00:00:00 GMT http://www.3dchem.com/molecules.asp?id=492http://www.3dchem.com/molecules.asp?id=492Miglustat has been proven to deliver important benefits to people with type 1 Gaucher disease. Dr. Philippe Gaucher first described, in 1882, the symptoms now known as Gaucher Disease. aucher Disease results from a specific enzyme deficiency in the body, caused by a genetic mutation received from both parents. It is an autosomal recessive disease and the most prevalent Lysosomal Storage Disorder (LSD), with an incidence of about 1 in 20,000 live births. It is also the most common genetic disease affecting Ashkenazi Jewish people (Eastern, Central and Northern European ancestry), with a carrier frequency of 1 in 10 (Dr. John Barranger and Dr. Ed Ginns 1989). This pan ethnic disease involves many organ systems, such as liver, spleen, lungs, brain, metabolism and bone marrow. Thu, 2 Aug 2012 00:00:00 GMT http://www.3dchem.com/molecules.asp?id=491http://www.3dchem.com/molecules.asp?id=491Febrifugine is a quinazolinone alkaloid first isolated from Chinese herb Dichroa febrifuga, but also found in the garden plant Hydrangea. Febrifugine has antimalarial properties and the halogenated derivative halofuginone is used in veterinary medicine as a coccidiostat.Mon, 2 Jul 2012 00:00:00 GMT http://www.3dchem.com/molecules.asp?id=490http://www.3dchem.com/molecules.asp?id=490Camptothecin is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I). It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native to China used as a cancer treatment in Traditional Chinese Medicine.Sat, 2 Jun 2012 00:00:00 GMT http://www.3dchem.com/molecules.asp?id=489http://www.3dchem.com/molecules.asp?id=489Topotecan is a chemotherapeutic agent that is a topoisomerase inhibitor. It is a water-soluble derivative of camptothecin. It is used in form of the hydrochloride to treat ovarian cancer and lung cancer, as well as other cancer types.Wed, 2 May 2012 00:00:00 GMT http://www.3dchem.com/molecules.asp?id=488http://www.3dchem.com/molecules.asp?id=488Prostratin is a protein kinase C activator found in the bark of the mamala tree of Samoa, Homalanthus nutans (Euphorbiaceae). While prostratin was originally isolated and identified as a new phorbol from species of the genus Pimelea (Thymelaceae) in Australia, the antiviral activity of prostratin was discovered during research on the traditional knowledge of Samoan healers in Falealupo village by ethnobotanist Paul Alan Cox and a team at the U.S. National Cancer Institute. Samoan healers use the mamala tree to treat hepatitis. Research indicated that prostratin has potential to be useful in the treatment of HIV as it could flush viral reservoirs in latently infected CD4+ T-cells.Mon, 2 Apr 2012 00:00:00 GMT