Home > Marcain (Molecule of the Month for June 2007)
|
|
|---|
click on the picture above
to interact |
 |
C18 H28 N2 O |
Bupivacaine is a local anaesthetic drug belonging to the amino amide group. Bupivacaine is used for local anaesthesia including infiltration, nerve block, epidural, and intrathecal anaesthesia. Bupivacaine often is administered by epidural injection before total hip arthroplasty.
Compared to other local anaesthetics, bupivacaine is markedly cardiotoxic. However, adverse drug reactions are rare when it is administered correctly. Most problems relate to administration technique (resulting in systemic exposure) or pharmacological effects of anesthesia, though allergic reactions can sometimes occur.
Systemic exposure to excessive quantities of bupivacaine mainly result in central nervous system (CNS) and cardiovascular effects – CNS effects usually occur at lower blood plasma concentrations and additional cardiovascular effects present at higher concentrations, though cardiovascular collapse may also occur with low concentrations. CNS effects may include CNS excitation (nervousness, tingling around the mouth, tinnitus, tremor, dizziness, blurred vision, seizures) followed by depression (drowsiness, loss of consciousness, respiratory depression and apnea). Cardiovascular effects include hypotension, bradycardia, arrhythmias, and/or cardiac arrest – some of which may be due to hypoxemia secondary to respiratory depression.
Formal Chemical Name (IUPAC)
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
References
http://en.wikipedia.org/wiki/Bupivacaine
Update by Karl Harrison
(Molecule of the Month for
June 2007
)