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Eloxatin (Molecule of the Month for November 2005)

Oxaliplatin , DACH Platinum Oxalate



ELOXATIN, an anticancer (chemotherapy) drug, is given with two other anticancer drugs, 5-fluorouracil (5-FU) and leucovorin (LV), and is used to treat adults with stage III colon cancer after surgery to remove the tumor. ELOXATIN is also used to treat adults with advanced colorectal cancer.

It is a new platinum based drug. It has the large 1,2-diaminocyclohexane (DACH) bound to the platinum centre, and this bulky group prevents DNA repair mechanisms working correctly. The platinum centre binds to DNA strands and thus prevents DNA replication and transcription, and therefore slows cancer tumor growth.

Formal Chemical Name (IUPAC)

References

http://www.eloxatin.com/

Picture of Eloxatin

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Eloxatin structure
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Picture of Eloxatin

C8H12N2O4Pt



Update by Karl Harrison
(Molecule of the Month for November 2005 )