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Salbutamol (Molecule of the Month for December 2017)

Ventolin, Proventil, Albuterol



Salbutamol is a medication that opens up the medium and large airways in the lungs.[6] It is used to treat asthma including asthma attacks, exercise-induced bronchoconstriction, and chronic obstructive pulmonary disease (COPD). It may also be used to treat high blood potassium levels. Salbutamol is usually used with an inhaler or nebulizer but is also available as a pill and intravenous solution. Onset of action of the inhaled version is typically within 15 minutes and lasts for two to six hours.

Salbutamol is typically used to treat bronchospasm (due to any cause – allergic asthma or exercise-induced), as well as chronic obstructive pulmonary disease. It is also one of the most common medicines used in rescue inhalers (short-term bronchodilators to alleviate asthma attacks). As a β2 agonist, salbutamol also has use in obstetrics. Intravenous salbutamol can be used as a tocolytic to relax the uterine smooth muscle to delay premature labor. While preferred over agents such as atosiban and ritodrine, its role has largely been replaced by the calcium channel blocker nifedipine, which is more effective, better tolerated, and administered orally

There is no compelling evidence that salbutamol and other β2 agonists can increase performance in healthy athletes.[26] In spite of this, salbutamol required "a declaration of Use in accordance with the International Standard for Therapeutic Use Exemptions" under the 2010 WADA prohibited list. This requirement was relaxed when the 2011 list was published to permit the use of "salbutamol (maximum 1600 micrograms over 24 hours) and salmeterol when taken by inhalation in accordance with the manufacturers’ recommended therapeutic regimen."[27][28] Abuse of the drug may be confirmed by detection of its presence in plasma or urine, typically exceeding 1000 ng/L. The window of detection for urine testing is on the order of just 24 hours, given the relatively short elimination half-life of the drug,There is no compelling evidence that salbutamol and other β2 agonists can increase performance in healthy athletes. In spite of this, salbutamol required "a declaration of Use in accordance with the International Standard for Therapeutic Use Exemptions" under the 2010 WADA prohibited list. This requirement was relaxed when the 2011 list was published to permit the use of "salbutamol (maximum 1600 micrograms over 24 hours) and salmeterol when taken by inhalation in accordance with the manufacturers’ recommended therapeutic regimen." Abuse of the drug may be confirmed by detection of its presence in plasma or urine, typically exceeding 1000 ng/L. The window of detection for urine testing is on the order of just 24 hours, given the relatively short elimination half-life of the drug,

Formal Chemical Name (IUPAC)
(RS)-4-[2-(tert-Butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol

References

https://en.wikipedia.org/wiki/Salbutamol

Picture of Salbutamol 3D model

click on the picture of  Salbutamol above to interact
with the 3D model of the
Salbutamol structure
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Picture of Salbutamol

C13 H21 N O3



Update by Karl Harrison
(Molecule of the Month for December 2017 )

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