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Ondansetron (Molecule of the Month for November 2016)

Zofran, Emeset, Emetron, Ondemet



Ondansetron is mainly to treat nausea and vomiting following chemotherapy. Its effects are thought to be on both peripheral and central nerves. One part is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata, the other is a blockage of serotonin receptors in the chemoreceptor trigger zone. It does not have much effect on vomiting due to motion sickness.

Ondansetron was developed around 1984 by scientists working at Glaxo's laboratories in London. It is currently marketed by GlaxoSmithKline (GSK) under the trade name ZofranŽ; other manufacturers include Cipla Ltd. (Emeset), Gedeon Richter Ltd. Emetron), and Zentiva a.s. (Ondemet).

Granisetron is often given intravenously about 30 minutes before beginning chemotherapy.

Formal Chemical Name (IUPAC)
9-methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-2,3-dihydro-1H-carbazol-4(9H)-one

References

http://en.wikipedia.org/wiki/Zofran

Picture of Ondansetron 3D model

click on the picture of  Ondansetron above to interact
with the 3D model of the
Ondansetron structure
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Picture of Ondansetron

C18H19N3O



Update by Karl Harrison
(Molecule of the Month for November 2016 )

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