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Mifepristone (Molecule of the Month for April 2006)

RU-486



Mifepristone is a synthetic steroid with anti-progestagenic and anti-glucocorticoid effects. It is useful in humans as an abortifacient in the first two months of pregnancy.

Mifepristone is sold by Danco Laboratories and is approved to terminate pregnancy up to 49 days after the beginning of the latest menstrual cycle. It blocks a hormone required to sustain a pregnancy. When followed two days later by another medicine, misoprostol, to induce contractions, the pregnancy is terminated.

Formal Chemical Name (IUPAC)
(8S,11R,13S,14S,17S)-11-(4-(dimethylamino)phenyl)-17-hydroxy-13-methyl-17-(prop-1-ynyl)-1,2,7,8,11,12,13,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3(14H)-one

References

http://en.wikipedia.org/wiki/RU-486

Picture of Mifepristone

click on the picture above to interact
with the 3D model of the
Mifepristone structure
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Picture of Mifepristone

C29 H35 N O2



Update by Karl Harrison
(Molecule of the Month for April 2006 )