3DChem.com - Chemistry, Structures & 3D Molecules a visual and interactive website showcasing the beautiful world of chemistry

Loratadine (Molecule of the Month for July 1999)

Clarityn



Long-Acting Antihistamine/Extended Release Decongestant

Loratadine is a long-acting tricyclic antihistamine with selective peripheral histamine H1-receptor antagonistic activity. Human histamine skin wheal studies following single and repeated oral doses of loratadine have shown that the drug exhibits an antihistaminic effect beginning within 1 to 3 hours, reaching a maximum at 8 to 12 hours and lasting in excess of 24 hours.There was no evidence of tolerance to this effect developing after 28 days of dosing with loratadine.

Pharmacokinetic studies following showed that loratadine is rapidly absorbed and extensively metabolized to an active metabolite (descarboethoxyloratadine)

Formal Chemical Name (IUPAC)

Picture of Loratadine 3D model

click on the picture of  Loratadine above to interact
with the 3D model of the
Loratadine structure
(this will open a new browser window)

Picture of Loratadine

C22 H23 Cl N2 O2



Update by Karl Harrison
(Molecule of the Month for July 1999 )

Stacks Image 34 All the images on this web site are are made available with a Creative Commons Attribution license and so can be used as long as the attribution
© Karl Harrison 3DChem.com is written with the image. High resolution images and illustrations are available on request.