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Khellin (Molecule of the Month for March 2013)

Amicardine; Corafurone; Methafrone; Kelourin; Rykellin; Visammin



Khellin is a furanochromone, an organic compound which is derivative of chromone (1,4-benzopyrone) and furan. It has lipophilic properties and causes vasodilation (widening of blood vessels).

It is found in the plant Ammi visnaga which has been used in Egyptian folk medicine. In Egypt, the plant "Khella" was used for renal colic. The incidence of renal colic was due mostly to schistosomiasis infections and stone formation. The plant mixture had diuretic properties that were seen to relieve renal colic in Egyptian folk medicine. After the chemical compound khellin was identified, people began to study its properties. It was found to relax the ureter and coronary arteries.

It is not used as a systemic medication because it is difficult to absorb and causes a range of undesirable side effects such as dizziness, headache, gastrointestinal disorders and nausea.

Formal Chemical Name (IUPAC)
4,9-Dimethoxy-7-methylfuro[3,2-g]chromen-5-one

References

http://en.wikipedia.org/wiki/Khellin

Picture of Khellin 3D model

click on the picture of  Khellin above to interact
with the 3D model of the
Khellin structure
(this will open a new browser window)

Picture of Khellin

C14H12O5



Update by Karl Harrison
(Molecule of the Month for March 2013 )

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