3DChem.com - Chemistry, Structures & 3D Molecules a visual and interactive website showcasing the beautiful world of chemistry

Hydrochlorothiazide (Molecule of the Month for March 2003)



Hydrochlorothiazide is a drug used to treat high blood pressure.

It is a thiazide diuretic and exhibits the typical action of one. Its action is to deplete the bodyís sodium stores. It also reduces the levels of chloride, bicarbonate, phosphate and magnesium. The drug also reduces the loss of calcium.

The drug inhibits cellís reabsorption of NaCl. Thiazides are organic anions and bind to the site of the Cl- on the sodium chloride transporter molecule preventing it from picking up NaCl. The depletion of NaCl stores in the body reduces blood pressure and cardiac output. After a few weeks cardiac output returns to a normal level. Distal calcium reabsorption is also increased.

Formal Chemical Name (IUPAC)

Picture of Hydrochlorothiazide

click on the picture above to interact
with the 3D model of the
Hydrochlorothiazide structure
(this will open a new browser window)

Picture of Hydrochlorothiazide

C7 H8 Cl N3 O4 S2



Update by Karl Harrison
(Molecule of the Month for March 2003 )