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Elvitegravir (Molecule of the Month for May 2017)

Vitekta



Elvitegravir is an integrase inhibitor used to treat HIV infection. According to the results of the phase II clinical trial, patients taking once-daily elvitegravir boosted by ritonavir had greater reductions in viral load after 24 weeks compared to individuals randomized to receive a ritonavir-boosted protease inhibitor.

Elvitegravir inhibits the enzyme integrase of HIV-1, and of HIV-2 to a lesser extent. The virus needs this enzyme to integrate its genetic code into the host's DNA.

Formal Chemical Name (IUPAC)
(S)-6-(3-chloro-2-fluorobenzyl)-1-(1-hydroxy-3-methylbutan-2-yl)-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

References

https://en.wikipedia.org/wiki/Elvitegravir

Picture of Elvitegravir 3D model

click on the picture of  Elvitegravir above to interact
with the 3D model of the
Elvitegravir structure
(this will open a new browser window)

Picture of Elvitegravir

C23H23ClFNO5



Update by Karl Harrison
(Molecule of the Month for May 2017 )

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