Ecdysone (Molecule of the Month for October 2008)
Ecdysone is a steroidal prohormone of the major insect molting hormone 20-hydroxyecdysone, which is secreted from the prothoracic glands. Insect molting hormones (ecdysone and its homologues) are generally called ecdysteroids. Ecdysteroids act as moulting hormones of arthropods but also occur in other related phyla where they can play different roles.
In fruit flys (Drosophila melanogaster), an increase in ecdysone concentration induces the expression of genes coding for proteins that the larva requires, and it causes chromosome puffs (sites of high expression) to form.
Ecdysteroids also appear in many plants mostly as a protection agent (toxins or antifeedants) against herbivorous insects. These phytoecdysteroids have medicinal value and are part of herbal adaptogenic remedies like Cordyceps.
Formal Chemical Name (IUPAC)
Update by Karl Harrison
(Molecule of the Month for October 2008 )
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